Cardiologist

Board certification
Cardiovascular disease, internal medicine and interventional cardiology

Education
Cardiologist David Laxson earned his medical degree from the University of Washington School of Medicine in Seattle, Wash.  He completed residency, cardiology fellowship, and an interventional cardiology fellowship training at the University of Minnesota in Minneapolis, Minn. He is currently the Cardiology Program Director for Fairview Southdale, Director of the Catheterization Laboratory at Fairview Southdale Hospital, and Medical Director, Clinical Cardiology Research.

Special medical interests
Interventional cardiology and clinical cardiology research.

For appointments
952-924-9005

Clinic location
Minnesota Heart Clinic
305 East Nicollet Blvd.
Ridgeview Office Bldg.
Suite 372
Burnsville, MN 55337

Publications

Laxson DD, Dai XZ, Schwartz JS, Bache RJ:  Effects of atrial natriuretic peptide on coronary vascular resistance in the awake dog.  J Am Coll Card 1988;11:624-9

Laxson DD, Homans DC, Dai XZ, Sublett E, Bache RJ: Oxygen consumption and coronary reactivity in postischemic myocardium.  Circ Res 1989; 64:9-20.

Homans DC, Laxson DD, Sublett E, Lindstrom P, Bache RJ: Cumulative deterioration of myocardial function after repeated episodes of exercise induced ischemia.  Am J Physiol 1989; 25:H1462-H1471.

Wilson RF, Laxson DD, Lesser JR, White CW: Intense microvascular constriction after angioplasty of acute thrombotic coronary arterial lesions.  Lancet 1989; 5:807-811.

Laxson DD, Dai XZ, Nomans DC, Bache RJ: The role of a1- and a2-adrenergic receptors in mediating coronary vasoconstriction in hypoperfused ischemic myocardium during exercise.  Circ Res 1989; 65:1688-1697.

Foreman B, Dai XZ, Homans DC, Laxson DD, Bache RJ: Effect of atrial natriuretic peptide on coronary collateral blood flow.  Circ Res 1989; 65:1671-1678.

Bache RJ, Wright L, Laxson DD, Dai XZ: Effect of a coronary stenosis on myocardial blood flow during exercise in the chronically pressure overloaded hypertrophied left ventricle.  Circulation 1990;81:1967-1973.

Bache RJ, Laxson DD: Coronary atriolar vasoconstriction in myocardial ischemia: Coronary vasodilator reserve during ischemia.  Eur Heart J 1990; 11(Suppl B):5-9.

Wilson RF, Wyche K, Christensen BV, Zimmer SD, Laxson DD:  The effects of adenosine on human coronary arterial circulation.  Circ 1990; 82:1595-1606.

Homans DC, Laxson DD, Bache RJ: The effect of exercise intensity on regional function during and following exercise induced ischemia.  Circ 1991; 83:2029-2037.

Wilson RF, Christensen BV, Olivari MT, Simon A, White CW, Laxson DD:  Evidence for sympathetic innervation after orthotopic cardiac transplantation in humans.  Circ 1991; 83:1210-1220.

Laxson DD, Dai XZ, Homans DC, Bache RJ: Coronary vasodilator reserve in ischemic myocardium of the exercising dog.  Circ 1992; 85:313-322.

Wright L, Homans DC, Laxson DD, Dai XZ, Bache RJ:  Effect of serotonin and thromboxane A2 on blood flow through moderately well developed coronary collateral vessels.  J Am Coll Cardiol 1992; 19:687-693.

Wilson RF, Laxson DD:  Caveat emptor: A clinician’s guide to assessing the physiologic significance of arterial stenosis.  Card Cathet Diag 1993; 29:93-98.

Wilson RF, Laxson DD, Christensen BV, McGinn AL, Kubo SH.  Regional difference in sympathetic reinnervation after human orthotopic cardiac transplantation.  Circulation 1993; 88:165-171.

Altman J, Dulas D, Pavek T, Laxson DD, Homans DC, Bache Rj:  Endothelial function in well-developed canine coronary collateral vessels.  Am J Physiol 264 (Heart Circ Physiol 33):H567-H572, 1993.

Laxson DD, Homas DL, Bache RJ:  Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise.  Am J Physiol 265 (Heart Circ Physiol 34):H1471-H1477, 1993.

Dunker DJ, Laxson DD, Lindstrom P, Bache RJ:  Endogenous adenosine and coronary vasoconstriction in hypoperfused myocardium during exercise.  Cardiovascular Res 1993; 27:1592-1597.

Homans DC, Pavek T, Laxson DD, Bache RJ.  Recovery of transmural and subepicardial wall thickening following subendocardial infarction.  J Am Col Cardiol: 1994; 24:1109-1116.

Lurie KL, Schultz J, Remole S, Asso A, Pineda E, Benditt D, Fetter J, Laxson DD:  Constrictive pericardial disease secondary to epicardial implantable cardiac defibrillator patches:  Treatment with pericardial stripping and implantation of a nonthoracotomy lead system.  Am Heart J:  1994; 128:623-625.

Faxson DP et al:  Effect of high dose angiotensin-converting enzyme inhibition on restenosis:  Final results of the MARCATOR Study, a multicenter, double blind, placebo controlled trial of cilazapril.  J Am Coll Cardiol:  1995; 25:362-369.

Bittle JA et al:  Treatment with bivalirudin (Hirulog) as compared with heparin during coronary angioplasty for unstable or post infarction angina.  NEJM 1995; 333:764-769.

TIMI 11A Investigators: Dose-ranging trial of enoxaparin for unstable angina: results of TIMI 11A.  JACC 1997;29:1474-82.

Henry TD, Satran D, Knox LL, Iacarella CL, Laxson, DD, Antman EM.  Are activated clotting times helpful in the management of anticoagulation with subcutaneous low-molecular-weight heparin?  Am Heart J 2001; 142:590-593.

Abstracts

Bache RJ, Dai XZ, Chen DG, Simon AB, Laxson DD, Schwartz JS:  Coronary Vasomotor Effects of Atrial Natriuretic Factor in the Dog.  Circ 1986; 74(Suppl II):II-437.

Laxson DD, Homans DC, Bache RJ:  Myocardial blood flow and oxygen consumption in stunned myocardium.  J Am Coll Cardiol 1987; 9(2):125A.

Homans DC, Sublett E, Laxson DD, Nesbitt T, Bache RJ: Repetitive episodes of exercise-induced ischemia result in progressive regional left ventricular dysfunction.  Clin Res 1986; 34(4):943A.

Laxson DD, Dai XZ, Homans DC, Bache RJ: Coronary vasodilator reserve during ischemia.  Circ 1987; 76(Suppl II):IV-146.

Laxson DD, Dai XZ, Sublett E, Nesbitt T, Lindstrom P, Bache RJ:  Coronary vasomotor effects of atrial natriurectic peptide in the conscious dog.  Circ 1987; 76 (Suppl II):IV-320.

Dai XZ, Laxson DD, Hautamaa PV, Schwartz JS, Bache RJ: Alpha-Adrenergic Coronary Vasoconstrictor Receptor Subtypes in Awake Dogs.  American College of Cardiology, 37th Scientific Session, March, 1988.

Laxson DD, Dai XZ, Sublett E, Stark R, Bache RJ: Adrenergic vasoconstriction limits coronary blood flow during exercise induced ischemia.  Circ 1988; 78:11-411.

Wilson RF, Christensen B, Zimmer SD, Laxson DD, White CW: Effects of adenosine on the coronary circulation in humans.  J Am Coll Cardiol 1989; 13(2):132A.

Laxson DD, Dai XZ, Stark RP, Bache RJ: Endogenous adenosine contributes to coronary vasodilation in ischemic myocardium during exercise.  Circ 1989; 80: II-548.

Wright L, Dai XZ, Laxson DD, Homans DC, Bache RJ: Vasoconstriction of collateral vessels by serotonin and U46619.  Circ 1989; 80:II-551.

Path G, Robitaille PM, Tristani-Firouzi M, Merkle H, Laxson DD, Homans DC, Sublett E, Zhang J, Lindstrom P, From AHL, Bache RJ, Ugurbil K: 31P NMR spectroscopy detects regional ischemia during graded coronary stenosis.  Circ 1989; 80:II-587.

Homans DC, Dai XZ, Laxson DD, Sublett E, Pavek T, Bache RJ: Recovery of subepicardial and transmural function following subendocardial infarct.  Circ 1989; 80:II-98.

McGinn AL, Christensen BV, Meyer SM, Simon A, Kubo SH, Laxson DD, Wilson RF:  Nitroglycerin induced coronary vasodilation is impaired early after cardiac transplantation.  J Am Coll Cardiol 1991; 17:309A.

Bache RJ, Foreman BF, Pavek T, Lindstrom P, Laxson DD, Homans DC: Acute, but not chronic, reduction of myocardial blood flow results in marked subendocardial underperfusion during exercise.  Circ 1990; 82:III-381.

Path GJ, Tristani-Firouzi M, Zhang J, Homans DC, Laxson DD, Robitaille PM, Merkle H, Lindstrom P, Pavek T, From AH, Bache RJ, Ugurbil K: Effects of a coronary stenosis on transmural myocardial high energy phosphates and systolic function.  Circ 1990; 82:III-65.

McGinn AL, Christensen BV, Meyer SM, Simon A, Kubo SH, Laxson DD, Wilson RF: Reduced resting epicardial coronary constrictor tone early after cardiac transplantation.  Internat Soc Heart Transplantation 11th Scientific Sessions, April 1991.

Wilson RF, McGinn AL, Laxson DD, Christensen BV, Kubo SH: Sympathetic reinnervation after cardiac transplantation in humans:  Time course and regional heterogeneity.  Internal Soc Heart Transplantation, 11th Scientific Sessions, April 1991.

Altman J, Dulas D, Laxson DD, Homans DC, Bache RJ:  Endothelial function in well-developed canine coronary collateral vessels.  Circ 1991; 84:II-97.

Wilson RF, McGinn AL. Laxson DD, Christensen BV, Simon AB, Johnson TH, Kubo SH.  Regional differences in sympathetic reinnervation after cardiac transplantation.  Circ 1991; 84: II-489.

McGinn Al, Meyer SM, Christensen BV, Simon AB, Johnson TH, Kubo SH, Laxson DD, Wilson RF:  Can sympathetic reinnervation affect coronary resistance after human cardiac transplantation?  Circ 1991; 84:II-493.

Henry TD, Laxson DD, McGinn AZ, Zimmer SD, Wilson RF:  Chest pain after successful angioplasty:  Evidence for microvascular dysfunction.  J Am Coll Cardiol 1992; 19:384A.

Burke MN, Homans DC, Laxson DD, Christensen BV, Kubo SH, Wilson RF:  Can sympathetic reinnervation after human cardiac transplantation affect left ventricular function.  Circulation 1992; 86(Supp I): I-434.

Laxson DD, Pavek T, Crampton M, Zhang XW:  Coronary angioplasty results in microvascular vasoconstriction.  Clin Res 1994;42:360A.

Hollenbaugh D, Laxson DD.  Hyperglycemia impairs coronary microvascular endothelium-dependent vasodilation.  Circulation 1995; 92(8): I-451.

King SB, Willerson JT, Ross AM, et al for the RESTORE Investigators:  Time course of reduction in adverse events following angioplasty using a IIb/IIIa receptor blocker, tirofiban: the RESTORE trial.  Circulation 1996; 94(8):I-199.

Gibson M, Goel M, Dotani I, et al for the RESTORE Investigators:  The post-PTCA frame count and mortality in RESTORE.  Circulation 1996; 94(8): I-85.

Antman EM, McCabe CH, Marble SJ, et al- the TIMI 11A group:  Dose ranging trial for enoxaparin for unstable angina: results of TIMI 11A.  Circulation 1996; 94(8): I-554.

Anderson VH, Bertrand ME, Hall BH, et al for the RESTORE Investigators:  Bleeding risk with platelet inhibition using tirofiban: the RESTORE trial.  Circulation 1996; 94(8): I-553.

Cannon CP, Novotny WF, McCabe CH, et al and the TIMI Investigators:  Evaluation of the oral glycoprotein IIb/IIIa antagonist Ro 48-3657 in patients post acute coronary syndromes:  Primary results of the TIMI 12 trial.  Circulation 1996; 94(8): I-552.

Henry TD, Knox LK, Iacarella CL, Laxson DD:  Are ACTs helpful in the management of anticoagulation with low molecular weight heparin?  J Am Coll Cardiol 1997; 29:153A.

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